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Zhejiang Fangge Pharmaceutical Co., Ltd Zhejiang Fangge Pharmaceutical Co., Ltd

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Рейши Увеличить

Растворимый в воде экстракт (порошок) из клеток Рейши или Линчжи (Ganoderma). 
Упаковка из 15 металлизированных пакетиков.
По 2 грамма экстракта в пакетике.
Общий вес препарата – 30 грамм. 

Применяется для профилактики и лечения онкологических заболеваний:
простаты, предстательной железы, легких, молочной железы, шейки матки, тела матки, печени, почки, мочевого пузыря, бронха, меланоме, лимфоме, глиобластоме и астроцитоме, миеломной болезни, саркоме, лейкозе

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В наличии

1 850 руб

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При покупке этого экстракта Bы получите 1850 бонусных баллов.

Рейши. Ganoderma lucidum. 
Гриб ганодерма. Линчжи.

Состав: 100% тело Ganoderma lucidum
Содержание полисахаридов: 35%.

Свидетельство о государственной регистрации:
№ RU.77.99.88.003.Е.003322.02.15 от 11.02.2015 г.
Бланк №0262517 (проверить на сайте Госреестра)

Одобрен к применению Государственным комитетом по делам здравоохранения и планового деторождения Китайской Народной Республики и Китайской академией медицинских наук. Включен в клиническую практику для профилактики и лечения онкологических заболеваний. Является заменителем препарата Lentinan™ (Лентинан).

Химический состав действующих веществ:
полисахариды: бета-D-глюкан (G-1);
ганодераны А,В,С;
GL-1(арабиноксилоглюкан);
FA, FI, FI-1, D-6;
тритерпеноиды: ганодеровые кислоты A,B,C,D,R,S,G,F,H,K,Y;
ганодермическая кислота;
стероид ganodosterone;
ненасыщенная жирная олеиновая кислота;
полипептид Ling Zhi -8 (LZ-8).

Фармакодинамика:
Противоопухолевое воздействие через усиление механизма противоопухолевой резистентности организма:
направленная активация различных иммунных исполнительных элементов (возрастание NK-клеточной активности, усиление формирования цитотоксических Т-лимфоцитов (ЦТЛ), активизация макрофагов);
увеличение их жизненного цикла;
угнетение тритерпенами роста опухоли;
потенцирование различных лимфокинов (интерлейкина 1, 2 и 6);
увеличение синтеза альфа-ФНО (фактора некроза опухолей);
увеличение производства интерферона-альфа, и улучшение действия интерферона-гамма в 2-4 раза;
увеличение выработки перфоринов;
восстановление сниженной иммунологической реактивности, которая наблюдается при облучении или химиотерапии;
противодействие депрессивному воздействию цитостатиков на количество белых и красных кровяных клеток;
при химиотерапии и облучении облегчение таких симптомов, как: слабость, анорексия, рвота, сухость во рту, спонтанное потение и боль;
иммуномодуляция;
болеутоляющее действие;
противовоспалительные свойства;
гепатопротективный эффект, улучшение функционального состояния печени, уменьшение энзимопатии.

Основное действие:
Подавляет рост опухоли, останавливает распространения метастаз, включает процесс разрушения и уничтожения раковых клеток и метастаз, останавливает разрастание сосудов опухолей, поднимает уровень иммунитета, сильно поддерживает организм в период химио- и лучевой терапии, снижает до минимума негативные последствия химио- и лучевой терапии, улучшает показатели анализов крови, притупляет болезненные ощущения, сильно увеличивает срок жизни.
Читать подробно: КАК ЭКСТРАКТ ВОЗДЕЙСТВУЕТ НА ОПУХОЛЬ (лечебное действие).

Суточная дозировка:
Профилактическая: 2 раза в день по 1 пакетику за 30-60 минут до еды
Лечебная: 2-3 раза в день по одному пакетику за 30-60 минут до еды 
Для достижения наилучших результатов рекомендуется принимать согласно правилам методики "ПРОГМА".
Необходима консультация специалиста.

Не рекомендуется принимать более двух месяцев подряд. 

Описание:
Мелкодисперсный порошок, полностью растворимый в воде. Цвет может меняться от светлокоричневого до тёмно-коричневого.

Способ применения:
Высыпать содержимое пакетика в стакан со 100 мл горячей ~ 80°С воды, размешать до полного растворения порошка, охладить до приемлемой температуры. Выпить.

Побочные действия:
При повышенной чувствительности, в редких случаях, возможно появление лёгкой диспепсии. Также редко наблюдались аллергические реакции, в виде крапивницы, на компоненты экстракта.

Противопоказания:
Только индивидуальная непереносимость. 
Беременность, лактация - не проводились клинические испытания в этих группах.
Не желательно применять экстракт детям до 8 лет.

Взаимодействие с другими лекарственными средствами, БАДами и продуктами:
Хорошо сочетается с цитостатиками. Также при терапии даёт более выраженный эффект в сочетании с экстрактами из других грибов. В этом случае дозы приёма экстракта должны быть скорректированы специалистом. Хорошо сочетается с другими БАДами. 

Условия хранения: 
Хранить при комнатной температуре (15-25 °С) в оригинальной упаковке.

Производитель: 

Zhejiang Fangge Pharmaceutical Co., Ltd
QINGYUAN, CHINESE MUSHROOM CITY, No. 1 
ECOLOGICAL ENVIRONMENT TOWN OF CHINA,
ZHEJIANG PROVINCE, 
CHINA.

Стандарт производства и качества: GMP (Good Manufacturing Practice)

Особые условия:
Перед применением обязательно проконсультируйтесь со специалистом
Биологически Активная Добавка - не является медицинским препаратом.
Не содержит ГМО.

Оплата заказов: 
- банковской картой, при оформлении заказа на сайте
- банковским переводом на наш счет 
- наличными в офисе (только в Санкт-Петербурге)
- наличными при получении заказа (только в Санкт-Петербурге)

Доставка заказов:
- заказы по России и СНГ отправляются курьерскими службами СДЭК или ЕМС-Почта России
- доставка по Санкт-Петербургу осуществляется собственными курьерами

Полные условия оплаты и доставки заказов смотрите ЗДЕСЬ.

Среднее время доставки занимает 3-6 дней. Курьер привезет заказ по указанному адресу в рабочее время. Отслеживать перемещения заказов по России можно на сайтах почтовых служб. Вы всегда будете в курсе где находится отправление и узнаете ориентировочную дату доставки. В момент получения дополнительных доплат не требуется.

Methanolic Extract of Ganoderma lucidum Induces Autophagy of AGS Human Gastric Tumor Cells.

Reis FS, Lima RT, Morales P, Ferreira IC, Vasconcelos MH.

Molecules. 2015 Sep 29;20(10):17872-82. doi: 10.3390/molecules201017872.

Immunomodulatory Protein from Ganoderma microsporum Induces Pro-Death Autophagy through Akt-mTOR-p70S6K Pathway Inhibition in Multidrug Resistant Lung Cancer Cells.

Chiu LY, Hu ME, Yang TY, Hsin IL, Ko JL, Tsai KJ, Sheu GT.

PLoS One. 2015 May 6;10(5):e0125774. doi: 10.1371/journal.pone.0125774. eCollection 2015.

Ganoderma lucidum polysaccharide extract inhibits hepatocellular carcinoma growth by downregulating regulatory T cells accumulation and function by inducing microRNA-125b.

Li A, Shuai X, Jia Z, Li H, Liang X, Su D, Guo W.

J Transl Med. 2015 Mar 26;13:100. doi: 10.1186/s12967-015-0465-5.

Tissue invasion and metastasis: Molecular, biological and clinical perspectives.

Jiang WG, Sanders AJ, Katoh M, Ungefroren H, Gieseler F, Prince M, Thompson SK, Zollo M, Spano D, Dhawan P, Sliva D, Subbarayan PR, Sarkar M, Honoki K, Fujii H, Georgakilas AG, Amedei A, Niccolai E, Amin A, Ashraf SS, Ye L, Helferich WG, Yang X, Boosani CS, Guha G, Ciriolo MR, Aquilano K, Chen S, Azmi AS, Keith WN, Bilsland A, Bhakta D, Halicka D, Nowsheen S, Pantano F, Santini D.

Semin Cancer Biol. 2015 Dec;35 Suppl:S244-75. doi: 10.1016/j.semcancer.2015.03.008. Epub 2015 Apr 10. Review.

Ganoderma Lucidum Pharmacopuncture for Teating Ethanol-induced Chronic Gastric Ulcers in Rats.

Park JH, Jang KJ, Kim CH, Kim JH, Kim YK, Yoon HM.

J Pharmacopuncture. 2015 Mar;18(1):72-8. doi: 10.3831/KPI.2015.18.008.

Exceedingly biocompatible and thin-layered reduced graphene oxide nanosheets using an eco-friendly mushroom extract strategy.

Muthoosamy K, Bai RG, Abubakar IB, Sudheer SM, Lim HN, Loh HS, Huang NM, Chia CH, Manickam S.

Int J Nanomedicine. 2015 Feb 20;10:1505-19. doi: 10.2147/IJN.S75213. eCollection 2015.

Ganoderma lucidum inhibits proliferation of human ovarian cancer cells by suppressing VEGF expression and up-regulating the expression of connexin 43.

Dai S, Liu J, Sun X, Wang N.

BMC Complement Altern Med. 2014 Nov 5;14:434. doi: 10.1186/1472-6882-14-434.

A comprehensive review of the structure elucidation and biological activity of triterpenoids from Ganoderma spp.

Xia Q, Zhang H, Sun X, Zhao H, Wu L, Zhu D, Yang G, Shao Y, Zhang X, Mao X, Zhang L, She G.

Molecules. 2014 Oct 30;19(11):17478-535. doi: 10.3390/molecules191117478. Review.

Fungal beta glucan protects radiation induced DNA damage in human lymphocytes.

Pillai TG, Maurya DK, Salvi VP, Janardhanan KK, Nair CK.

Ann Transl Med. 2014 Feb;2(2):13. doi: 10.3978/j.issn.2305-5839.2014.02.02.

CARI III inhibits tumor growth in a melanoma-bearing mouse model through induction of G0/G1 cell cycle arrest.

Park HJ.

Molecules. 2014 Sep 12;19(9):14383-95. doi: 10.3390/molecules190914383.

Bioactive proteins and peptides isolated from Chinese medicines with pharmaceutical potential.

Wong KL, Wong RN, Zhang L, Liu WK, Ng TB, Shaw PC, Kwok PC, Lai YM, Zhang ZJ, Zhang Y, Tong Y, Cheung HP, Lu J, Sze SC.

Chin Med. 2014 Jul 19;9:19. doi: 10.1186/1749-8546-9-19. eCollection 2014. Review.

Khz-cp (crude polysaccharide extract obtained from the fusion of Ganoderma lucidum and Polyporus umbellatus mycelia) induces apoptosis by increasing intracellular calcium levels and activating P38 and NADPH oxidase-dependent generation of reactive oxygen species in SNU-1 cells.

Kim TH, Kim JS, Kim ZH, Huang RB, Chae YL, Wang RS.

BMC Complement Altern Med. 2014 Jul 10;14:236. doi: 10.1186/1472-6882-14-236.

A green chemistry approach for synthesizing biocompatible gold nanoparticles.

Gurunathan S, Han J, Park JH, Kim JH.

Nanoscale Res Lett. 2014 May 21;9(1):248. doi: 10.1186/1556-276X-9-248. eCollection 2014.

Ganoderma lucidum polysaccharides target a Fas/caspase dependent pathway to induce apoptosis in human colon cancer cells.

Liang Z, Guo YT, Yi YJ, Wang RC, Hu QL, Xiong XY.

Asian Pac J Cancer Prev. 2014;15(9):3981-6.

Clinical characteristics of gynecologic cancer patients who respond to salvage treatment with Lingzhi.

Suprasert P, Apichartpiyakul C, Sakonwasun C, Nitisuwanraksa P, Phuackchantuck R.

Asian Pac J Cancer Prev. 2014;15(10):4193-6.

Chemical characterization and antitumor activities of polysaccharide extracted from Ganodermalucidum.

Liang Z, Yi Y, Guo Y, Wang R, Hu Q, Xiong X.

Int J Mol Sci. 2014 May 22;15(5):9103-16. doi: 10.3390/ijms15059103.

An in vitro evaluation of graphene oxide reduced by Ganoderma spp. in human breast cancer cells (MDA-MB-231).

Gurunathan S, Han J, Park JH, Kim JH.

Int J Nanomedicine. 2014 Apr 8;9:1783-97. doi: 10.2147/IJN.S57735. eCollection 2014.

The multifaceted effects of polysaccharides isolated from Dendrobium huoshanense on immune functions with the induction of interleukin-1 receptor antagonist (IL-1ra) in monocytes.

Lin J, Chang YJ, Yang WB, Yu AL, Wong CH.

PLoS One. 2014 Apr 4;9(4):e94040. doi: 10.1371/journal.pone.0094040. eCollection 2014.

In vivo and in vitro anti-tumor effects of fungal extracts.

Wu HT, Lu FH, Su YC, Ou HY, Hung HC, Wu JS, Yang YC, Chang CJ.

Molecules. 2014 Feb 21;19(2):2546-56. doi: 10.3390/molecules19022546.

Triterpene-loaded microemulsion using Coix lacryma-jobi seed extract as oil phase for enhanced antitumor efficacy: preparation and in vivo evaluation.

Qu D, He J, Liu C, Zhou J, Chen Y.

Int J Nanomedicine. 2014;9:109-19. doi: 10.2147/IJN.S54796. Epub 2013 Dec 19.

Green synthesis of silver nanoparticles using Ganoderma neo-japonicum Imazeki: a potential cytotoxic agent against breast cancer cells.

Gurunathan S, Raman J, Abd Malek SN, John PA, Vikineswary S.

Int J Nanomedicine. 2013;8:4399-413. doi: 10.2147/IJN.S51881. Epub 2013 Nov 15.

Ganoderiol A-enriched extract suppresses migration and adhesion of MDA-MB-231 cells by inhibiting FAK-SRC-paxillin cascade pathway.

Wu GS, Song YL, Yin ZQ, Guo JJ, Wang SP, Zhao WW, Chen XP, Zhang QW, Lu JJ, Wang YT.

PLoS One. 2013 Oct 29;8(10):e76620. doi: 10.1371/journal.pone.0076620. eCollection 2013.

Anti-lung cancer activity through enhancement of immunomodulation and induction of cell apoptosis of total triterpenes extracted from Ganoderma luncidum (Leyss. ex Fr.) Karst.

Feng L, Yuan L, Du M, Chen Y, Zhang MH, Gu JF, He JJ, Wang Y, Cao W.

Molecules. 2013 Aug 19;18(8):9966-81. doi: 10.3390/molecules18089966.

Immunization of fucose-containing polysaccharides from Reishi mushroom induces antibodies to tumor-associated Globo H-series epitopes.

Liao SF, Liang CH, Ho MY, Hsu TL, Tsai TI, Hsieh YS, Tsai CM, Li ST, Cheng YY, Tsao SM, Lin TY, Lin ZY, Yang WB, Ren CT, Lin KI, Khoo KH, Lin CH, Hsu HY, Wu CY, Wong CH.

Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13809-14. doi: 10.1073/pnas.1312457110. Epub 2013 Aug 1.

Anticancer activity of Amauroderma rude.

Jiao C, Xie YZ, Yang X, Li H, Li XM, Pan HH, Cai MH, Zhong HM, Yang BB.

PLoS One. 2013 Jun 20;8(6):e66504. doi: 10.1371/journal.pone.0066504. Print 2013.

Modulatory effect of Ganoderma lucidum on expression of xenobiotic enzymes, oxidant-antioxidant and hormonal status in 7,12-dimethylbenz(a)anthracene-induced mammary carcinoma in rats.

Deepalakshmi K, Mirunalini S.

Pharmacogn Mag. 2013 Apr;9(34):167-75. doi: 10.4103/0973-1296.111286.

Ganoderma tsugae Extract Inhibits Growth of HER2-Overexpressing Cancer Cells via Modulation of HER2/PI3K/Akt Signaling Pathway.

Kuo HP, Hsu SC, Ou CC, Li JW, Tseng HH, Chuang TC, Liu JY, Chen SJ, Su MH, Cheng YC, Chou WY, Kao MC.

Evid Based Complement Alternat Med. 2013;2013:219472. doi: 10.1155/2013/219472. Epub 2013 Apr 7.

Traditional Chinese medicine syndrome-related herbal prescriptions in treatment of malignant tumors.

Liu Z, Chen S, Cai J, Zhang E, Lan L, Zheng J, Liao L, Yang X, Zhou C, Du J.

J Tradit Chin Med. 2013 Feb;33(1):19-26.

<i>Ganoderma lucidum</i> polysaccharides counteract inhibition on CD71 and FasL expression by culture supernatant of B16F10 cells upon lymphocyte activation.

Sun LX, Lin ZB, Duan XS, Lu J, Ge ZH, Li M, Xing EH, Lan TF, Jiang MM, Yang N, Li WD.

Exp Ther Med. 2013 Apr;5(4):1117-1122. Epub 2013 Jan 29.

Anti-tumor effects of Ganoderma lucidum (reishi) in inflammatory breast cancer in in vivo and in vitro models.

Suarez-Arroyo IJ, Rosario-Acevedo R, Aguilar-Perez A, Clemente PL, Cubano LA, Serrano J, Schneider RJ, Martínez-Montemayor MM.

PLoS One. 2013;8(2):e57431. doi: 10.1371/journal.pone.0057431. Epub 2013 Feb 28.

Apoptotic and Immune Restoration Effects of Ganoderic Acids Define a New Prospective for Complementary Treatment of Cancer.

Radwan FF, Perez JM, Haque A.

J Clin Cell Immunol. 2011 Dec 11;S3:4.

Mushroom Ganoderma lucidum prevents colitis-associated carcinogenesis in mice.

Sliva D, Loganathan J, Jiang J, Jedinak A, Lamb JG, Terry C, Baldridge LA, Adamec J, Sandusky GE, Dudhgaonkar S.

PLoS One. 2012;7(10):e47873. doi: 10.1371/journal.pone.0047873. Epub 2012 Oct 30.

Khz (fusion of Ganoderma lucidum and Polyporus umbellatus mycelia) induces apoptosis by increasing intracellular calcium levels and activating JNK and NADPH oxidase-dependent generation of reactive oxygen species.

Kim TH, Kim Js, Kim Zh, Huang RB, Wang RS.

PLoS One. 2012;7(10):e46208. doi: 10.1371/journal.pone.0046208. Epub 2012 Oct 8.

Synergistic Cytotoxic Effects of Ganoderma lucidum and Bacillus Calmette Guérin on Premalignant Urothelial HUC-PC Cells and Its Regulation on Proinflammatory Cytokine Secretion.

Yuen JW, Gohel MD, Ng CF.

Evid Based Complement Alternat Med. 2012;2012:147896. doi: 10.1155/2012/147896. Epub 2012 Aug 28.

Ergosterol peroxide isolated from Ganoderma lucidum abolishes microRNA miR-378-mediated tumor cells on chemoresistance.

Wu QP, Xie YZ, Deng Z, Li XM, Yang W, Jiao CW, Fang L, Li SZ, Pan HH, Yee AJ, Lee DY, Li C, Zhang Z, Guo J, Yang BB.

PLoS One. 2012;7(8):e44579. doi: 10.1371/journal.pone.0044579. Epub 2012 Aug 30.

Extracellular polysaccharides produced by Ganoderma formosanum stimulate macrophage activation via multiple pattern-recognition receptors.

Wang CL, Lu CY, Pi CC, Zhuang YJ, Chu CL, Liu WH, Chen CJ.

BMC Complement Altern Med. 2012 Aug 10;12:119. doi: 10.1186/1472-6882-12-119.

Enhanced production of ganoderic acids and cytotoxicity of Ganoderma lucidum using solid-medium culture.

You BJ, Lee HZ, Chung KR, Lee MH, Huang MJ, Tien N, Chan CW, Kuo YH.

Biosci Biotechnol Biochem. 2012;76(8):1529-34. Epub 2012 Aug 7.

BreastDefend™ prevents breast-to-lung cancer metastases in an orthotopic animal model of triple-negative human breast cancer.

Jiang J, Thyagarajan-Sahu A, Loganathan J, Eliaz I, Terry C, Sandusky GE, Sliva D.

Oncol Rep. 2012 Oct;28(4):1139-45. doi: 10.3892/or.2012.1936. Epub 2012 Jul 26.

Ganoderma tsugae Induces S Phase Arrest and Apoptosis in Doxorubicin-Resistant Lung Adenocarcinoma H23/0.3 Cells via Modulation of the PI3K/Akt Signaling Pathway.

Yu YH, Kuo HP, Hsieh HH, Li JW, Hsu WH, Chen SJ, Su MH, Liu SH, Cheng YC, Chen CY, Kao MC.

Evid Based Complement Alternat Med. 2012;2012:371286. doi: 10.1155/2012/371286. Epub 2012 Jun 26.

Ginseng and Ganoderma lucidum use after breast cancer diagnosis and quality of life: a report from the Shanghai Breast Cancer Survival Study.

Bao PP, Lu W, Cui Y, Zheng Y, Gu K, Chen Z, Zheng W, Shu XO.

PLoS One. 2012;7(6):e39343. doi: 10.1371/journal.pone.0039343. Epub 2012 Jun 20.

Inhibition of lysosome degradation on autophagosome formation and responses to GMI, an immunomodulatory protein from Ganoderma microsporum.

Hsin IL, Sheu GT, Jan MS, Sun HL, Wu TC, Chiu LY, Lue KH, Ko JL.

Br J Pharmacol. 2012 Nov;167(6):1287-300. doi: 10.1111/j.1476-5381.2012.02073.x.

Recent developments in mushrooms as anti-cancer therapeutics: a review.

Patel S, Goyal A.

3 Biotech. 2012 Mar;2(1):1-15. Epub 2011 Nov 25.

Spore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial.

Zhao H, Zhang Q, Zhao L, Huang X, Wang J, Kang X.

Evid Based Complement Alternat Med. 2012;2012:809614. doi: 10.1155/2012/809614. Epub 2011 Dec 10.

Anti-invasive activity of ethanol extracts of Ganoderma lucidum through tightening of tight junctions and inhibition of matrix metalloproteinase activities in human gastric carcinoma cells.

Jang KJ, Son IS, Shin DY, Yoon HM, Choi YH.

J Acupunct Meridian Stud. 2011 Dec;4(4):225-35. doi: 10.1016/j.jams.2011.09.013. Epub 2011 Oct 20.

Recombinant Lz-8 from Ganoderma lucidum induces endoplasmic reticulum stress-mediated autophagic cell death in SGC-7901 human gastric cancer cells.

Liang C, Li H, Zhou H, Zhang S, Liu Z, Zhou Q, Sun F.

Oncol Rep. 2012 Apr;27(4):1079-89. doi: 10.3892/or.2011.1593. Epub 2011 Dec 14.

Ling Zhi-8 mediates p53-dependent growth arrest of lung cancer cells proliferation via the ribosomal protein S7-MDM2-p53 pathway.

Wu CT, Lin TY, Hsu HY, Sheu F, Ho CM, Chen EI.

Carcinogenesis. 2011 Dec;32(12):1890-6. doi: 10.1093/carcin/bgr221. Epub 2011 Oct 7.

ReishiMax, mushroom based dietary supplement, inhibits adipocyte differentiation, stimulates glucose uptake and activates AMPK.

Thyagarajan-Sahu A, Lane B, Sliva D.

BMC Complement Altern Med. 2011 Sep 19;11:74. doi: 10.1186/1472-6882-11-74.

Ganoderma lucidum (Reishi) inhibits cancer cell growth and expression of key molecules in inflammatory breast cancer.

Martínez-Montemayor MM, Acevedo RR, Otero-Franqui E, Cubano LA, Dharmawardhane SF.

Nutr Cancer. 2011;63(7):1085-94. doi: 10.1080/01635581.2011.601845. Epub 2011 Sep 2.

Study of the extraction process and in vivo inhibitory effect of ganoderma triterpenes in oral mucosa cancer.

Gao Y, Zhang R, Zhang J, Gao S, Gao W, Zhang H, Wang H, Han B.

Molecules. 2011 Jun 24;16(7):5315-32. doi: 10.3390/molecules16075315.

"And what other medications are you taking?".

Gordan JD, Chay WY, Kelley RK, Ko AH, Choo SP, Venook AP.

J Clin Oncol. 2011 Apr 10;29(11):e288-91. doi: 10.1200/JCO.2010.32.8054. Epub 2011 Jan 18. No abstract available. 

Herbal therapy use by cancer patients: a literature review on case reports.

Olaku O, White JD.

Eur J Cancer. 2011 Mar;47(4):508-14. doi: 10.1016/j.ejca.2010.11.018. Epub 2010 Dec 23. Review.

Promoting effects of Ganoderma lucidum polysaccharides on B16F10 cells to activate lymphocytes.

Sun LX, Lin ZB, Li XJ, Li M, Lu J, Duan XS, Ge ZH, Song YX, Xing EH, Li WD.

Basic Clin Pharmacol Toxicol. 2011 Mar;108(3):149-54. doi: 10.1111/j.1742-7843.2010.00632.x. Epub 2010 Oct 22.

Induction of apoptosis by ethanol extracts of Ganoderma lucidum in human gastric carcinoma cells.

Jang KJ, Han MH, Lee BH, Kim BW, Kim CH, Yoon HM, Choi YH.

J Acupunct Meridian Stud. 2010 Mar;3(1):24-31. doi: 10.1016/S2005-2901(10)60004-0.

Medical mushrooms used for biochemical failure after radical treatment for prostate cancer: an open-label study.

Yoshimura K, Kamoto T, Ogawa O, Matsui S, Tsuchiya N, Tada H, Murata K, Yoshimura K, Habuchi T, Fukushima M.

Int J Urol. 2010 Jun;17(6):548-54. doi: 10.1111/j.1442-2042.2010.02528.x. Epub 2010 Apr 19.

Ganoderic acid T inhibits tumor invasion in vitro and in vivo through inhibition of MMP expression.

Chen NH, Liu JW, Zhong JJ.

Pharmacol Rep. 2010 Jan-Feb;62(1):150-63.

Morgana/chp-1, a ROCK inhibitor involved in centrosome duplication and tumorigenesis.

Ferretti R, Palumbo V, Di Savino A, Velasco S, Sbroggiò M, Sportoletti P, Micale L, Turco E, Silengo L, Palumbo G, Hirsch E, Teruya-Feldstein J, Bonaccorsi S, Pandolfi PP, Gatti M, Tarone G, Brancaccio M.

Dev Cell. 2010 Mar 16;18(3):486-95. doi: 10.1016/j.devcel.2009.12.020.

Ganoderic Acid DM: An Alternative Agent for the Treatment of Advanced Prostate Cancer.

Johnson BM, Doonan BP, Radwan FF, Haque A.

Open Prost Cancer J. 2010 Jan 1;3:78-85.

A water-soluble extract from cultured medium of Ganoderma lucidum (Reishi) mycelia attenuates the small intestinal injury induced by anti-cancer drugs.

Kashimoto N, Ishii S, Myojin Y, Ushijima M, Hayama M, Watanabe H.

Oncol Lett. 2010 Jan;1(1):63-68. Epub 2010 Jan 1.

Supplements for immune enhancement in hematologic malignancies.

Sze DM, Chan GC.

Hematology Am Soc Hematol Educ Program. 2009:313-9. doi: 10.1182/asheducation-2009.1.313. Review.

Ganoderma lucidum extracts inhibited leukemia WEHI-3 cells in BALB/c mice and promoted an immune response in vivo.

Chang YH, Yang JS, Yang JL, Wu CL, Chang SJ, Lu KW, Lin JJ, Hsia TC, Lin YT, Ho CC, Wood WG, Chung JG.

Biosci Biotechnol Biochem. 2009 Dec;73(12):2589-94. Epub 2009 Dec 7.

The effect of a novel botanical agent TBS-101 on invasive prostate cancer in animal models.

Evans S, Dizeyi N, Abrahamsson PA, Persson J.

Anticancer Res. 2009 Oct;29(10):3917-24.

Gandoderma lucidum extract promotes immune responses in normal BALB/c mice In vivo.

Chang YH, Yang JS, Yang JL, Wu CL, Chang SJ, Lu KW, Kuo CL, Hsia TC, Chung JG.

In Vivo. 2009 Sep-Oct;23(5):755-9.

Complementary therapies, herbs, and other OTC agents: Reishi mushroom.

Cassileth B.

Oncology (Williston Park). 2009 Jul;23(8):728. No abstract available. 

Ganoderma lucidum Polysaccharides Induce Macrophage-Like Differentiation in Human Leukemia THP-1 Cells via Caspase and p53 Activation.

Hsu JW, Huang HC, Chen ST, Wong CH, Juan HF.

Evid Based Complement Alternat Med. 2011;2011:358717. doi: 10.1093/ecam/nep107. Epub 2011 Jan 4.

Functional expression of LZ-8, a fungal immunomodulatory protein from Ganoderma lucidium in Pichia pastoris.

Xue Q, Ding Y, Shang C, Jiang C, Zhao M.

J Gen Appl Microbiol. 2008 Dec;54(6):393-8.

Ganoderic acid Me inhibits tumor invasion through down-regulating matrix metalloproteinases 2/9 gene expression.

Chen NH, Liu JW, Zhong JJ.

J Pharmacol Sci. 2008 Oct;108(2):212-6.

Possible involvement of long chain fatty acids in the spores of Ganoderma lucidum (Reishi Houshi) to its anti-tumor activity.

Fukuzawa M, Yamaguchi R, Hide I, Chen Z, Hirai Y, Sugimoto A, Yasuhara T, Nakata Y.

Biol Pharm Bull. 2008 Oct;31(10):1933-7.

Ganoderma lucidum polysaccharides can induce human monocytic leukemia cells into dendritic cells with immuno-stimulatory function.

Chan WK, Cheung CC, Law HK, Lau YL, Chan GC.

J Hematol Oncol. 2008 Jul 21;1:9. doi: 10.1186/1756-8722-1-9.

Toxicity of a traditional Chinese medicine, Ganoderma lucidum, in children with cancer.

Gill SK, Rieder MJ.

Can J Clin Pharmacol. 2008 Summer;15(2):e275-85. Epub 2008 Jul 4.

Effects of the antlered form of Ganoderma lucidum on tumor growth and metastasis in cyclophosphamide-treated mice.

Nonaka Y, Ishibashi H, Nakai M, Shibata H, Kiso Y, Abe S.

Biosci Biotechnol Biochem. 2008 Jun;72(6):1399-408. Epub 2008 Jun 7.

Interaction of Ganoderma triterpenes with doxorubicin and proteomic characterization of the possible molecular targets of Ganoderma triterpenes.

Yue QX, Xie FB, Guan SH, Ma C, Yang M, Jiang BH, Liu X, Guo DA.

Cancer Sci. 2008 Jul;99(7):1461-70. doi: 10.1111/j.1349-7006.2008.00824.x. Epub 2008 Apr 16.

[Changes of serum interferon-gamma levels in mice bearing S-180 tumor and the interventional effect of immunomodulators].

Li L, Lei LS, Yu CL.

Nan Fang Yi Ke Da Xue Xue Bao. 2008 Jan;28(1):65-8. Chinese. 

Proteomics characterization of the cytotoxicity mechanism of ganoderic acid D and computer-automated estimation of the possible drug target network.

Yue QX, Cao ZW, Guan SH, Liu XH, Tao L, Wu WY, Li YX, Yang PY, Liu X, Guo DA.

Mol Cell Proteomics. 2008 May;7(5):949-61. doi: 10.1074/mcp.M700259-MCP200. Epub 2007 Dec 31.

[Effect of Ganoderma lucidum polysaccharides peptide on invasion of human lung carcinoma cells in vitro].

Cao QZ, Lin SQ, Wang SZ.

Beijing Da Xue Xue Bao. 2007 Dec 18;39(6):653-6. Chinese. 

Lucidenic acid inhibits PMA-induced invasion of human hepatoma cells through inactivating MAPK/ERK signal transduction pathway and reducing binding activities of NF-kappaB and AP-1.

Weng CJ, Chau CF, Hsieh YS, Yang SF, Yen GC.

Carcinogenesis. 2008 Jan;29(1):147-56. Epub 2007 Nov 16.

Ganoderma lucidum polysaccharides in human monocytic leukemia cells: from gene expression to network construction.

Cheng KC, Huang HC, Chen JH, Hsu JW, Cheng HC, Ou CH, Yang WB, Chen ST, Wong CH, Juan HF.

BMC Genomics. 2007 Nov 9;8:411.

Antioxidant small phenolic ingredients in Inonotus obliquus (persoon) Pilat (Chaga).

Nakajima Y, Sato Y, Konishi T.

Chem Pharm Bull (Tokyo). 2007 Aug;55(8):1222-6.

[Effect of Ganoderma lucidum polysaccharides on tumor cell nucleotide content and cell cycle in S180 ascitic tumor-bearing mice].

Li JJ, Lei LS, Yu CL, Zhu ZG, Zhang Q, Wu SG.

Nan Fang Yi Ke Da Xue Xue Bao. 2007 Jul;27(7):1003-5. Chinese. 

Response of human dendritic cells to different immunomodulatory polysaccharides derived from mushroom and barley.

Chan WK, Law HK, Lin ZB, Lau YL, Chan GC.

Int Immunol. 2007 Jul;19(7):891-9. Epub 2007 Jul 2.

Functional expression of FIP-gts, a fungal immunomodulatory protein from Ganoderma tsugae in Sf21 insect cells.

Jinn TR, Wu CM, Tu WC, Ko JL, Tzen JT.

Biosci Biotechnol Biochem. 2006 Nov;70(11):2627-34. Epub 2006 Nov 7.

Anti-tumor activities of the antlered form of Ganoderma lucidum in allogeneic and syngeneic tumor-bearing mice.

Nonaka Y, Shibata H, Nakai M, Kurihara H, Ishibashi H, Kiso Y, Tanaka T, Yamaguchi H, Abe S.

Biosci Biotechnol Biochem. 2006 Sep;70(9):2028-34. Epub 2006 Sep 7.

New anticancer agents: in vitro and in vivo evaluation of the antitumor and antimetastatic actions of various compounds isolated from medicinal plants.

Kimura Y.

In Vivo. 2005 Jan-Feb;19(1):37-60. Review.

[Progress in research on Ganoderma lucidium spore].

Zhang W, Zeng YS.

Zhong Xi Yi Jie He Xue Bao. 2004 Nov;2(6):463-5. Review. Chinese. No abstract available. 

Medicinal mushroom extracts inhibit ras-induced cell transformation and the inhibitory effect requires the presence of normal cells.

Hsiao WL, Li YQ, Lee TL, Li N, You MM, Chang ST.

Carcinogenesis. 2004 Jul;25(7):1177-83.

Antitumor and anti-angiogenic activity of Ganoderma lucidum polysaccharides peptide.

Cao QZ, Lin ZB.

Acta Pharmacol Sin. 2004 Jun;25(6):833-8.

Isoflavone aglycon produced by culture of soybean extracts with basidiomycetes and its anti-angiogenic activity.

Miura T, Yuan L, Sun B, Fujii H, Yoshida M, Wakame K, Kosuna K.

Biosci Biotechnol Biochem. 2002 Dec;66(12):2626-31.

Ganoderma lucidum extract induces cell cycle arrest and apoptosis in MCF-7 human breast cancercell.

Hu H, Ahn NS, Yang X, Lee YS, Kang KS.

Int J Cancer. 2002 Nov 20;102(3):250-3.

Effects of polysaccharides (FI0-c) from mycelium of Ganoderma tsugae on proinflammatory cytokine production by THP-1 cells and human PBMC (II).

Gao XX, Wang BX, Fei XF, Zhang J, Gong YJ, Minami M, Nagata T, Ikejima T.

Acta Pharmacol Sin. 2000 Dec;21(12):1186-92.

Effects of polysaccharides (FI0-b) from mycelium of Ganoderma tsugae on proinflammatory cytokine production by THP-1 cells and human PBMC (I).

Gao XX, Fei XF, Wang BX, Zhang J, Gong YJ, Minami M, Nagata T, Ikejima T.

Acta Pharmacol Sin. 2000 Dec;21(12):1179-85.

Solution properties of antitumor sulfated derivative of alpha-(1-->3)-D-glucan from Ganodermalucidum.

Zhang L, Zhang M, Zhou Q, Chen J, Zeng F.

Biosci Biotechnol Biochem. 2000 Oct;64(10):2172-8.

Ganoderma extract activates MAP kinases and induces the neuronal differentiation of rat pheochromocytoma PC12 cells.

Cheung WM, Hui WS, Chu PW, Chiu SW, Ip NY.

FEBS Lett. 2000 Dec 15;486(3):291-6.

In vitro chemopreventive effects of plant polysaccharides (Aloe barbadensis miller, Lentinus edodes, Ganoderma lucidum and Coriolus versicolor).

Kim HS, Kacew S, Lee BM.

Carcinogenesis. 1999 Aug;20(8):1637-40.

The anti-tumor effect of Ganoderma lucidum is mediated by cytokines released from activated macrophages and T lymphocytes.

Wang SY, Hsu ML, Hsu HC, Tzeng CH, Lee SS, Shiao MS, Ho CK.

Int J Cancer. 1997 Mar 17;70(6):699-705.

Antitumor active protein-containing glycans from the Chinese mushroom songshan lingzhi, Ganoderma tsugae mycelium.

Zhang J, Wang G, Li H, Zhuang C, Mizuno T, Ito H, Mayuzumi H, Okamoto H, Li J.

Biosci Biotechnol Biochem. 1994 Jul;58(7):1202-5.

Antitumor active polysaccharides from the Chinese mushroom Songshan lingzhi, the fruiting body of Ganoderma tsugae.

Wang G, Zhang J, Mizuno T, Zhuang C, Ito H, Mayuzumi H, Okamoto H, Li J.

Biosci Biotechnol Biochem. 1993 Jun;57(6):894-900.

Methanolic Extract of Ganoderma lucidum Induces Autophagy of AGS Human Gastric Tumor Cells.

Reis FS, Lima RT, Morales P, Ferreira IC, Vasconcelos MH.

Molecules. 2015 Sep 29;20(10):17872-82. doi: 10.3390/molecules201017872.

Immunomodulatory Protein from Ganoderma microsporum Induces Pro-Death Autophagy through Akt-mTOR-p70S6K Pathway Inhibition in Multidrug Resistant Lung Cancer Cells.

Chiu LY, Hu ME, Yang TY, Hsin IL, Ko JL, Tsai KJ, Sheu GT.

PLoS One. 2015 May 6;10(5):e0125774. doi: 10.1371/journal.pone.0125774. eCollection 2015.

Ganoderma lucidum polysaccharide extract inhibits hepatocellular carcinoma growth by downregulating regulatory T cells accumulation and function by inducing microRNA-125b.

Li A, Shuai X, Jia Z, Li H, Liang X, Su D, Guo W.

J Transl Med. 2015 Mar 26;13:100. doi: 10.1186/s12967-015-0465-5.

Tissue invasion and metastasis: Molecular, biological and clinical perspectives.

Jiang WG, Sanders AJ, Katoh M, Ungefroren H, Gieseler F, Prince M, Thompson SK, Zollo M, Spano D, Dhawan P, Sliva D, Subbarayan PR, Sarkar M, Honoki K, Fujii H, Georgakilas AG, Amedei A, Niccolai E, Amin A, Ashraf SS, Ye L, Helferich WG, Yang X, Boosani CS, Guha G, Ciriolo MR, Aquilano K, Chen S, Azmi AS, Keith WN, Bilsland A, Bhakta D, Halicka D, Nowsheen S, Pantano F, Santini D.

Semin Cancer Biol. 2015 Dec;35 Suppl:S244-75. doi: 10.1016/j.semcancer.2015.03.008. Epub 2015 Apr 10. Review.

Ganoderma Lucidum Pharmacopuncture for Teating Ethanol-induced Chronic Gastric Ulcers in Rats.

Park JH, Jang KJ, Kim CH, Kim JH, Kim YK, Yoon HM.

J Pharmacopuncture. 2015 Mar;18(1):72-8. doi: 10.3831/KPI.2015.18.008.

Exceedingly biocompatible and thin-layered reduced graphene oxide nanosheets using an eco-friendly mushroom extract strategy.

Muthoosamy K, Bai RG, Abubakar IB, Sudheer SM, Lim HN, Loh HS, Huang NM, Chia CH, Manickam S.

Int J Nanomedicine. 2015 Feb 20;10:1505-19. doi: 10.2147/IJN.S75213. eCollection 2015.

Ganoderma lucidum inhibits proliferation of human ovarian cancer cells by suppressing VEGF expression and up-regulating the expression of connexin 43.

Dai S, Liu J, Sun X, Wang N.

BMC Complement Altern Med. 2014 Nov 5;14:434. doi: 10.1186/1472-6882-14-434.

A comprehensive review of the structure elucidation and biological activity of triterpenoids from Ganoderma spp.

Xia Q, Zhang H, Sun X, Zhao H, Wu L, Zhu D, Yang G, Shao Y, Zhang X, Mao X, Zhang L, She G.

Molecules. 2014 Oct 30;19(11):17478-535. doi: 10.3390/molecules191117478. Review.

Fungal beta glucan protects radiation induced DNA damage in human lymphocytes.

Pillai TG, Maurya DK, Salvi VP, Janardhanan KK, Nair CK.

Ann Transl Med. 2014 Feb;2(2):13. doi: 10.3978/j.issn.2305-5839.2014.02.02.

CARI III inhibits tumor growth in a melanoma-bearing mouse model through induction of G0/G1 cell cycle arrest.

Park HJ.

Molecules. 2014 Sep 12;19(9):14383-95. doi: 10.3390/molecules190914383.

Bioactive proteins and peptides isolated from Chinese medicines with pharmaceutical potential.

Wong KL, Wong RN, Zhang L, Liu WK, Ng TB, Shaw PC, Kwok PC, Lai YM, Zhang ZJ, Zhang Y, Tong Y, Cheung HP, Lu J, Sze SC.

Chin Med. 2014 Jul 19;9:19. doi: 10.1186/1749-8546-9-19. eCollection 2014. Review.

Khz-cp (crude polysaccharide extract obtained from the fusion of Ganoderma lucidum and Polyporus umbellatus mycelia) induces apoptosis by increasing intracellular calcium levels and activating P38 and NADPH oxidase-dependent generation of reactive oxygen species in SNU-1 cells.

Kim TH, Kim JS, Kim ZH, Huang RB, Chae YL, Wang RS.

BMC Complement Altern Med. 2014 Jul 10;14:236. doi: 10.1186/1472-6882-14-236.

A green chemistry approach for synthesizing biocompatible gold nanoparticles.

Gurunathan S, Han J, Park JH, Kim JH.

Nanoscale Res Lett. 2014 May 21;9(1):248. doi: 10.1186/1556-276X-9-248. eCollection 2014.

Ganoderma lucidum polysaccharides target a Fas/caspase dependent pathway to induce apoptosis in human colon cancer cells.

Liang Z, Guo YT, Yi YJ, Wang RC, Hu QL, Xiong XY.

Asian Pac J Cancer Prev. 2014;15(9):3981-6.

Clinical characteristics of gynecologic cancer patients who respond to salvage treatment with Lingzhi.

Suprasert P, Apichartpiyakul C, Sakonwasun C, Nitisuwanraksa P, Phuackchantuck R.

Asian Pac J Cancer Prev. 2014;15(10):4193-6.

Chemical characterization and antitumor activities of polysaccharide extracted from Ganodermalucidum.

Liang Z, Yi Y, Guo Y, Wang R, Hu Q, Xiong X.

Int J Mol Sci. 2014 May 22;15(5):9103-16. doi: 10.3390/ijms15059103.

An in vitro evaluation of graphene oxide reduced by Ganoderma spp. in human breast cancer cells (MDA-MB-231).

Gurunathan S, Han J, Park JH, Kim JH.

Int J Nanomedicine. 2014 Apr 8;9:1783-97. doi: 10.2147/IJN.S57735. eCollection 2014.

The multifaceted effects of polysaccharides isolated from Dendrobium huoshanense on immune functions with the induction of interleukin-1 receptor antagonist (IL-1ra) in monocytes.

Lin J, Chang YJ, Yang WB, Yu AL, Wong CH.

PLoS One. 2014 Apr 4;9(4):e94040. doi: 10.1371/journal.pone.0094040. eCollection 2014.

In vivo and in vitro anti-tumor effects of fungal extracts.

Wu HT, Lu FH, Su YC, Ou HY, Hung HC, Wu JS, Yang YC, Chang CJ.

Molecules. 2014 Feb 21;19(2):2546-56. doi: 10.3390/molecules19022546.

Triterpene-loaded microemulsion using Coix lacryma-jobi seed extract as oil phase for enhanced antitumor efficacy: preparation and in vivo evaluation.

Qu D, He J, Liu C, Zhou J, Chen Y.

Int J Nanomedicine. 2014;9:109-19. doi: 10.2147/IJN.S54796. Epub 2013 Dec 19.

Green synthesis of silver nanoparticles using Ganoderma neo-japonicum Imazeki: a potential cytotoxic agent against breast cancer cells.

Gurunathan S, Raman J, Abd Malek SN, John PA, Vikineswary S.

Int J Nanomedicine. 2013;8:4399-413. doi: 10.2147/IJN.S51881. Epub 2013 Nov 15.

Ganoderiol A-enriched extract suppresses migration and adhesion of MDA-MB-231 cells by inhibiting FAK-SRC-paxillin cascade pathway.

Wu GS, Song YL, Yin ZQ, Guo JJ, Wang SP, Zhao WW, Chen XP, Zhang QW, Lu JJ, Wang YT.

PLoS One. 2013 Oct 29;8(10):e76620. doi: 10.1371/journal.pone.0076620. eCollection 2013.

Anti-lung cancer activity through enhancement of immunomodulation and induction of cell apoptosis of total triterpenes extracted from Ganoderma luncidum (Leyss. ex Fr.) Karst.

Feng L, Yuan L, Du M, Chen Y, Zhang MH, Gu JF, He JJ, Wang Y, Cao W.

Molecules. 2013 Aug 19;18(8):9966-81. doi: 10.3390/molecules18089966.

Immunization of fucose-containing polysaccharides from Reishi mushroom induces antibodies to tumor-associated Globo H-series epitopes.

Liao SF, Liang CH, Ho MY, Hsu TL, Tsai TI, Hsieh YS, Tsai CM, Li ST, Cheng YY, Tsao SM, Lin TY, Lin ZY, Yang WB, Ren CT, Lin KI, Khoo KH, Lin CH, Hsu HY, Wu CY, Wong CH.

Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13809-14. doi: 10.1073/pnas.1312457110. Epub 2013 Aug 1.

Anticancer activity of Amauroderma rude.

Jiao C, Xie YZ, Yang X, Li H, Li XM, Pan HH, Cai MH, Zhong HM, Yang BB.

PLoS One. 2013 Jun 20;8(6):e66504. doi: 10.1371/journal.pone.0066504. Print 2013.

Modulatory effect of Ganoderma lucidum on expression of xenobiotic enzymes, oxidant-antioxidant and hormonal status in 7,12-dimethylbenz(a)anthracene-induced mammary carcinoma in rats.

Deepalakshmi K, Mirunalini S.

Pharmacogn Mag. 2013 Apr;9(34):167-75. doi: 10.4103/0973-1296.111286.

Ganoderma tsugae Extract Inhibits Growth of HER2-Overexpressing Cancer Cells via Modulation of HER2/PI3K/Akt Signaling Pathway.

Kuo HP, Hsu SC, Ou CC, Li JW, Tseng HH, Chuang TC, Liu JY, Chen SJ, Su MH, Cheng YC, Chou WY, Kao MC.

Evid Based Complement Alternat Med. 2013;2013:219472. doi: 10.1155/2013/219472. Epub 2013 Apr 7.

Traditional Chinese medicine syndrome-related herbal prescriptions in treatment of malignant tumors.

Liu Z, Chen S, Cai J, Zhang E, Lan L, Zheng J, Liao L, Yang X, Zhou C, Du J.

J Tradit Chin Med. 2013 Feb;33(1):19-26.

<i>Ganoderma lucidum</i> polysaccharides counteract inhibition on CD71 and FasL expression by culture supernatant of B16F10 cells upon lymphocyte activation.

Sun LX, Lin ZB, Duan XS, Lu J, Ge ZH, Li M, Xing EH, Lan TF, Jiang MM, Yang N, Li WD.

Exp Ther Med. 2013 Apr;5(4):1117-1122. Epub 2013 Jan 29.

Anti-tumor effects of Ganoderma lucidum (reishi) in inflammatory breast cancer in in vivo and in vitro models.

Suarez-Arroyo IJ, Rosario-Acevedo R, Aguilar-Perez A, Clemente PL, Cubano LA, Serrano J, Schneider RJ, Martínez-Montemayor MM.

PLoS One. 2013;8(2):e57431. doi: 10.1371/journal.pone.0057431. Epub 2013 Feb 28.

Apoptotic and Immune Restoration Effects of Ganoderic Acids Define a New Prospective for Complementary Treatment of Cancer.

Radwan FF, Perez JM, Haque A.

J Clin Cell Immunol. 2011 Dec 11;S3:4.

Mushroom Ganoderma lucidum prevents colitis-associated carcinogenesis in mice.

Sliva D, Loganathan J, Jiang J, Jedinak A, Lamb JG, Terry C, Baldridge LA, Adamec J, Sandusky GE, Dudhgaonkar S.

PLoS One. 2012;7(10):e47873. doi: 10.1371/journal.pone.0047873. Epub 2012 Oct 30.

Khz (fusion of Ganoderma lucidum and Polyporus umbellatus mycelia) induces apoptosis by increasing intracellular calcium levels and activating JNK and NADPH oxidase-dependent generation of reactive oxygen species.

Kim TH, Kim Js, Kim Zh, Huang RB, Wang RS.

PLoS One. 2012;7(10):e46208. doi: 10.1371/journal.pone.0046208. Epub 2012 Oct 8.

Synergistic Cytotoxic Effects of Ganoderma lucidum and Bacillus Calmette Guérin on Premalignant Urothelial HUC-PC Cells and Its Regulation on Proinflammatory Cytokine Secretion.

Yuen JW, Gohel MD, Ng CF.

Evid Based Complement Alternat Med. 2012;2012:147896. doi: 10.1155/2012/147896. Epub 2012 Aug 28.

Ergosterol peroxide isolated from Ganoderma lucidum abolishes microRNA miR-378-mediated tumor cells on chemoresistance.

Wu QP, Xie YZ, Deng Z, Li XM, Yang W, Jiao CW, Fang L, Li SZ, Pan HH, Yee AJ, Lee DY, Li C, Zhang Z, Guo J, Yang BB.

PLoS One. 2012;7(8):e44579. doi: 10.1371/journal.pone.0044579. Epub 2012 Aug 30.

Extracellular polysaccharides produced by Ganoderma formosanum stimulate macrophage activation via multiple pattern-recognition receptors.

Wang CL, Lu CY, Pi CC, Zhuang YJ, Chu CL, Liu WH, Chen CJ.

BMC Complement Altern Med. 2012 Aug 10;12:119. doi: 10.1186/1472-6882-12-119.

Enhanced production of ganoderic acids and cytotoxicity of Ganoderma lucidum using solid-medium culture.

You BJ, Lee HZ, Chung KR, Lee MH, Huang MJ, Tien N, Chan CW, Kuo YH.

Biosci Biotechnol Biochem. 2012;76(8):1529-34. Epub 2012 Aug 7.

BreastDefend™ prevents breast-to-lung cancer metastases in an orthotopic animal model of triple-negative human breast cancer.

Jiang J, Thyagarajan-Sahu A, Loganathan J, Eliaz I, Terry C, Sandusky GE, Sliva D.

Oncol Rep. 2012 Oct;28(4):1139-45. doi: 10.3892/or.2012.1936. Epub 2012 Jul 26.

Ganoderma tsugae Induces S Phase Arrest and Apoptosis in Doxorubicin-Resistant Lung Adenocarcinoma H23/0.3 Cells via Modulation of the PI3K/Akt Signaling Pathway.

Yu YH, Kuo HP, Hsieh HH, Li JW, Hsu WH, Chen SJ, Su MH, Liu SH, Cheng YC, Chen CY, Kao MC.

Evid Based Complement Alternat Med. 2012;2012:371286. doi: 10.1155/2012/371286. Epub 2012 Jun 26.

Ginseng and Ganoderma lucidum use after breast cancer diagnosis and quality of life: a report from the Shanghai Breast Cancer Survival Study.

Bao PP, Lu W, Cui Y, Zheng Y, Gu K, Chen Z, Zheng W, Shu XO.

PLoS One. 2012;7(6):e39343. doi: 10.1371/journal.pone.0039343. Epub 2012 Jun 20.

Inhibition of lysosome degradation on autophagosome formation and responses to GMI, an immunomodulatory protein from Ganoderma microsporum.

Hsin IL, Sheu GT, Jan MS, Sun HL, Wu TC, Chiu LY, Lue KH, Ko JL.

Br J Pharmacol. 2012 Nov;167(6):1287-300. doi: 10.1111/j.1476-5381.2012.02073.x.

Recent developments in mushrooms as anti-cancer therapeutics: a review.

Patel S, Goyal A.

3 Biotech. 2012 Mar;2(1):1-15. Epub 2011 Nov 25.

Spore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial.

Zhao H, Zhang Q, Zhao L, Huang X, Wang J, Kang X.

Evid Based Complement Alternat Med. 2012;2012:809614. doi: 10.1155/2012/809614. Epub 2011 Dec 10.

Anti-invasive activity of ethanol extracts of Ganoderma lucidum through tightening of tight junctions and inhibition of matrix metalloproteinase activities in human gastric carcinoma cells.

Jang KJ, Son IS, Shin DY, Yoon HM, Choi YH.

J Acupunct Meridian Stud. 2011 Dec;4(4):225-35. doi: 10.1016/j.jams.2011.09.013. Epub 2011 Oct 20.

Recombinant Lz-8 from Ganoderma lucidum induces endoplasmic reticulum stress-mediated autophagic cell death in SGC-7901 human gastric cancer cells.

Liang C, Li H, Zhou H, Zhang S, Liu Z, Zhou Q, Sun F.

Oncol Rep. 2012 Apr;27(4):1079-89. doi: 10.3892/or.2011.1593. Epub 2011 Dec 14.

Ling Zhi-8 mediates p53-dependent growth arrest of lung cancer cells proliferation via the ribosomal protein S7-MDM2-p53 pathway.

Wu CT, Lin TY, Hsu HY, Sheu F, Ho CM, Chen EI.

Carcinogenesis. 2011 Dec;32(12):1890-6. doi: 10.1093/carcin/bgr221. Epub 2011 Oct 7.

ReishiMax, mushroom based dietary supplement, inhibits adipocyte differentiation, stimulates glucose uptake and activates AMPK.

Thyagarajan-Sahu A, Lane B, Sliva D.

BMC Complement Altern Med. 2011 Sep 19;11:74. doi: 10.1186/1472-6882-11-74.

Ganoderma lucidum (Reishi) inhibits cancer cell growth and expression of key molecules in inflammatory breast cancer.

Martínez-Montemayor MM, Acevedo RR, Otero-Franqui E, Cubano LA, Dharmawardhane SF.

Nutr Cancer. 2011;63(7):1085-94. doi: 10.1080/01635581.2011.601845. Epub 2011 Sep 2.

Study of the extraction process and in vivo inhibitory effect of ganoderma triterpenes in oral mucosa cancer.

Gao Y, Zhang R, Zhang J, Gao S, Gao W, Zhang H, Wang H, Han B.

Molecules. 2011 Jun 24;16(7):5315-32. doi: 10.3390/molecules16075315.

"And what other medications are you taking?".

Gordan JD, Chay WY, Kelley RK, Ko AH, Choo SP, Venook AP.

J Clin Oncol. 2011 Apr 10;29(11):e288-91. doi: 10.1200/JCO.2010.32.8054. Epub 2011 Jan 18. No abstract available. 

Herbal therapy use by cancer patients: a literature review on case reports.

Olaku O, White JD.

Eur J Cancer. 2011 Mar;47(4):508-14. doi: 10.1016/j.ejca.2010.11.018. Epub 2010 Dec 23. Review.

Promoting effects of Ganoderma lucidum polysaccharides on B16F10 cells to activate lymphocytes.

Sun LX, Lin ZB, Li XJ, Li M, Lu J, Duan XS, Ge ZH, Song YX, Xing EH, Li WD.

Basic Clin Pharmacol Toxicol. 2011 Mar;108(3):149-54. doi: 10.1111/j.1742-7843.2010.00632.x. Epub 2010 Oct 22.

Induction of apoptosis by ethanol extracts of Ganoderma lucidum in human gastric carcinoma cells.

Jang KJ, Han MH, Lee BH, Kim BW, Kim CH, Yoon HM, Choi YH.

J Acupunct Meridian Stud. 2010 Mar;3(1):24-31. doi: 10.1016/S2005-2901(10)60004-0.

Medical mushrooms used for biochemical failure after radical treatment for prostate cancer: an open-label study.

Yoshimura K, Kamoto T, Ogawa O, Matsui S, Tsuchiya N, Tada H, Murata K, Yoshimura K, Habuchi T, Fukushima M.

Int J Urol. 2010 Jun;17(6):548-54. doi: 10.1111/j.1442-2042.2010.02528.x. Epub 2010 Apr 19.

Ganoderic acid T inhibits tumor invasion in vitro and in vivo through inhibition of MMP expression.

Chen NH, Liu JW, Zhong JJ.

Pharmacol Rep. 2010 Jan-Feb;62(1):150-63.

Morgana/chp-1, a ROCK inhibitor involved in centrosome duplication and tumorigenesis.

Ferretti R, Palumbo V, Di Savino A, Velasco S, Sbroggiò M, Sportoletti P, Micale L, Turco E, Silengo L, Palumbo G, Hirsch E, Teruya-Feldstein J, Bonaccorsi S, Pandolfi PP, Gatti M, Tarone G, Brancaccio M.

Dev Cell. 2010 Mar 16;18(3):486-95. doi: 10.1016/j.devcel.2009.12.020.

Ganoderic Acid DM: An Alternative Agent for the Treatment of Advanced Prostate Cancer.

Johnson BM, Doonan BP, Radwan FF, Haque A.

Open Prost Cancer J. 2010 Jan 1;3:78-85.

A water-soluble extract from cultured medium of Ganoderma lucidum (Reishi) mycelia attenuates the small intestinal injury induced by anti-cancer drugs.

Kashimoto N, Ishii S, Myojin Y, Ushijima M, Hayama M, Watanabe H.

Oncol Lett. 2010 Jan;1(1):63-68. Epub 2010 Jan 1.

Supplements for immune enhancement in hematologic malignancies.

Sze DM, Chan GC.

Hematology Am Soc Hematol Educ Program. 2009:313-9. doi: 10.1182/asheducation-2009.1.313. Review.

Ganoderma lucidum extracts inhibited leukemia WEHI-3 cells in BALB/c mice and promoted an immune response in vivo.

Chang YH, Yang JS, Yang JL, Wu CL, Chang SJ, Lu KW, Lin JJ, Hsia TC, Lin YT, Ho CC, Wood WG, Chung JG.

Biosci Biotechnol Biochem. 2009 Dec;73(12):2589-94. Epub 2009 Dec 7.

The effect of a novel botanical agent TBS-101 on invasive prostate cancer in animal models.

Evans S, Dizeyi N, Abrahamsson PA, Persson J.

Anticancer Res. 2009 Oct;29(10):3917-24.

Gandoderma lucidum extract promotes immune responses in normal BALB/c mice In vivo.

Chang YH, Yang JS, Yang JL, Wu CL, Chang SJ, Lu KW, Kuo CL, Hsia TC, Chung JG.

In Vivo. 2009 Sep-Oct;23(5):755-9.

Complementary therapies, herbs, and other OTC agents: Reishi mushroom.

Cassileth B.

Oncology (Williston Park). 2009 Jul;23(8):728. No abstract available. 

Ganoderma lucidum Polysaccharides Induce Macrophage-Like Differentiation in Human Leukemia THP-1 Cells via Caspase and p53 Activation.

Hsu JW, Huang HC, Chen ST, Wong CH, Juan HF.

Evid Based Complement Alternat Med. 2011;2011:358717. doi: 10.1093/ecam/nep107. Epub 2011 Jan 4.

Functional expression of LZ-8, a fungal immunomodulatory protein from Ganoderma lucidium in Pichia pastoris.

Xue Q, Ding Y, Shang C, Jiang C, Zhao M.

J Gen Appl Microbiol. 2008 Dec;54(6):393-8.

Ganoderic acid Me inhibits tumor invasion through down-regulating matrix metalloproteinases 2/9 gene expression.

Chen NH, Liu JW, Zhong JJ.

J Pharmacol Sci. 2008 Oct;108(2):212-6.

Possible involvement of long chain fatty acids in the spores of Ganoderma lucidum (Reishi Houshi) to its anti-tumor activity.

Fukuzawa M, Yamaguchi R, Hide I, Chen Z, Hirai Y, Sugimoto A, Yasuhara T, Nakata Y.

Biol Pharm Bull. 2008 Oct;31(10):1933-7.

Ganoderma lucidum polysaccharides can induce human monocytic leukemia cells into dendritic cells with immuno-stimulatory function.

Chan WK, Cheung CC, Law HK, Lau YL, Chan GC.

J Hematol Oncol. 2008 Jul 21;1:9. doi: 10.1186/1756-8722-1-9.

Toxicity of a traditional Chinese medicine, Ganoderma lucidum, in children with cancer.

Gill SK, Rieder MJ.

Can J Clin Pharmacol. 2008 Summer;15(2):e275-85. Epub 2008 Jul 4.

Effects of the antlered form of Ganoderma lucidum on tumor growth and metastasis in cyclophosphamide-treated mice.

Nonaka Y, Ishibashi H, Nakai M, Shibata H, Kiso Y, Abe S.

Biosci Biotechnol Biochem. 2008 Jun;72(6):1399-408. Epub 2008 Jun 7.

Interaction of Ganoderma triterpenes with doxorubicin and proteomic characterization of the possible molecular targets of Ganoderma triterpenes.

Yue QX, Xie FB, Guan SH, Ma C, Yang M, Jiang BH, Liu X, Guo DA.

Cancer Sci. 2008 Jul;99(7):1461-70. doi: 10.1111/j.1349-7006.2008.00824.x. Epub 2008 Apr 16.

[Changes of serum interferon-gamma levels in mice bearing S-180 tumor and the interventional effect of immunomodulators].

Li L, Lei LS, Yu CL.

Nan Fang Yi Ke Da Xue Xue Bao. 2008 Jan;28(1):65-8. Chinese. 

Proteomics characterization of the cytotoxicity mechanism of ganoderic acid D and computer-automated estimation of the possible drug target network.

Yue QX, Cao ZW, Guan SH, Liu XH, Tao L, Wu WY, Li YX, Yang PY, Liu X, Guo DA.

Mol Cell Proteomics. 2008 May;7(5):949-61. doi: 10.1074/mcp.M700259-MCP200. Epub 2007 Dec 31.

[Effect of Ganoderma lucidum polysaccharides peptide on invasion of human lung carcinoma cells in vitro].

Cao QZ, Lin SQ, Wang SZ.

Beijing Da Xue Xue Bao. 2007 Dec 18;39(6):653-6. Chinese. 

Lucidenic acid inhibits PMA-induced invasion of human hepatoma cells through inactivating MAPK/ERK signal transduction pathway and reducing binding activities of NF-kappaB and AP-1.

Weng CJ, Chau CF, Hsieh YS, Yang SF, Yen GC.

Carcinogenesis. 2008 Jan;29(1):147-56. Epub 2007 Nov 16.

Ganoderma lucidum polysaccharides in human monocytic leukemia cells: from gene expression to network construction.

Cheng KC, Huang HC, Chen JH, Hsu JW, Cheng HC, Ou CH, Yang WB, Chen ST, Wong CH, Juan HF.

BMC Genomics. 2007 Nov 9;8:411.

Antioxidant small phenolic ingredients in Inonotus obliquus (persoon) Pilat (Chaga).

Nakajima Y, Sato Y, Konishi T.

Chem Pharm Bull (Tokyo). 2007 Aug;55(8):1222-6.

[Effect of Ganoderma lucidum polysaccharides on tumor cell nucleotide content and cell cycle in S180 ascitic tumor-bearing mice].

Li JJ, Lei LS, Yu CL, Zhu ZG, Zhang Q, Wu SG.

Nan Fang Yi Ke Da Xue Xue Bao. 2007 Jul;27(7):1003-5. Chinese. 

Response of human dendritic cells to different immunomodulatory polysaccharides derived from mushroom and barley.

Chan WK, Law HK, Lin ZB, Lau YL, Chan GC.

Int Immunol. 2007 Jul;19(7):891-9. Epub 2007 Jul 2.

Functional expression of FIP-gts, a fungal immunomodulatory protein from Ganoderma tsugae in Sf21 insect cells.

Jinn TR, Wu CM, Tu WC, Ko JL, Tzen JT.

Biosci Biotechnol Biochem. 2006 Nov;70(11):2627-34. Epub 2006 Nov 7.

Anti-tumor activities of the antlered form of Ganoderma lucidum in allogeneic and syngeneic tumor-bearing mice.

Nonaka Y, Shibata H, Nakai M, Kurihara H, Ishibashi H, Kiso Y, Tanaka T, Yamaguchi H, Abe S.

Biosci Biotechnol Biochem. 2006 Sep;70(9):2028-34. Epub 2006 Sep 7.

New anticancer agents: in vitro and in vivo evaluation of the antitumor and antimetastatic actions of various compounds isolated from medicinal plants.

Kimura Y.

In Vivo. 2005 Jan-Feb;19(1):37-60. Review.

[Progress in research on Ganoderma lucidium spore].

Zhang W, Zeng YS.

Zhong Xi Yi Jie He Xue Bao. 2004 Nov;2(6):463-5. Review. Chinese. No abstract available. 

Medicinal mushroom extracts inhibit ras-induced cell transformation and the inhibitory effect requires the presence of normal cells.

Hsiao WL, Li YQ, Lee TL, Li N, You MM, Chang ST.

Carcinogenesis. 2004 Jul;25(7):1177-83.

Antitumor and anti-angiogenic activity of Ganoderma lucidum polysaccharides peptide.

Cao QZ, Lin ZB.

Acta Pharmacol Sin. 2004 Jun;25(6):833-8.

Isoflavone aglycon produced by culture of soybean extracts with basidiomycetes and its anti-angiogenic activity.

Miura T, Yuan L, Sun B, Fujii H, Yoshida M, Wakame K, Kosuna K.

Biosci Biotechnol Biochem. 2002 Dec;66(12):2626-31.

Ganoderma lucidum extract induces cell cycle arrest and apoptosis in MCF-7 human breast cancercell.

Hu H, Ahn NS, Yang X, Lee YS, Kang KS.

Int J Cancer. 2002 Nov 20;102(3):250-3.

Effects of polysaccharides (FI0-c) from mycelium of Ganoderma tsugae on proinflammatory cytokine production by THP-1 cells and human PBMC (II).

Gao XX, Wang BX, Fei XF, Zhang J, Gong YJ, Minami M, Nagata T, Ikejima T.

Acta Pharmacol Sin. 2000 Dec;21(12):1186-92.

Effects of polysaccharides (FI0-b) from mycelium of Ganoderma tsugae on proinflammatory cytokine production by THP-1 cells and human PBMC (I).

Gao XX, Fei XF, Wang BX, Zhang J, Gong YJ, Minami M, Nagata T, Ikejima T.

Acta Pharmacol Sin. 2000 Dec;21(12):1179-85.

Solution properties of antitumor sulfated derivative of alpha-(1-->3)-D-glucan from Ganodermalucidum.

Zhang L, Zhang M, Zhou Q, Chen J, Zeng F.

Biosci Biotechnol Biochem. 2000 Oct;64(10):2172-8.

Ganoderma extract activates MAP kinases and induces the neuronal differentiation of rat pheochromocytoma PC12 cells.

Cheung WM, Hui WS, Chu PW, Chiu SW, Ip NY.

FEBS Lett. 2000 Dec 15;486(3):291-6.

In vitro chemopreventive effects of plant polysaccharides (Aloe barbadensis miller, Lentinus edodes, Ganoderma lucidum and Coriolus versicolor).

Kim HS, Kacew S, Lee BM.

Carcinogenesis. 1999 Aug;20(8):1637-40.

The anti-tumor effect of Ganoderma lucidum is mediated by cytokines released from activated macrophages and T lymphocytes.

Wang SY, Hsu ML, Hsu HC, Tzeng CH, Lee SS, Shiao MS, Ho CK.

Int J Cancer. 1997 Mar 17;70(6):699-705.

Antitumor active protein-containing glycans from the Chinese mushroom songshan lingzhi, Ganoderma tsugae mycelium.

Zhang J, Wang G, Li H, Zhuang C, Mizuno T, Ito H, Mayuzumi H, Okamoto H, Li J.

Biosci Biotechnol Biochem. 1994 Jul;58(7):1202-5.

Antitumor active polysaccharides from the Chinese mushroom Songshan lingzhi, the fruiting body of Ganoderma tsugae.

Wang G, Zhang J, Mizuno T, Zhuang C, Ito H, Mayuzumi H, Okamoto H, Li J.

Biosci Biotechnol Biochem. 1993 Jun;57(6):894-900.

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