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Zhejiang Fangge Pharmaceutical Co., Ltd Zhejiang Fangge Pharmaceutical Co., Ltd

Новое

Содержание полисахаридов: 45%.
Применяется на любых стадиях онкологических заболеваний:
легкого, печени, почки, пищевода, тонкого кишечника, толстого кишечника, простаты, гортаноглотки, молочной железы, поджелудочной железы, шейки матки, тела матки, яичника, мочевого пузыря, прямой кишки, бронха, меланоме, лимфоме, глиобластоме и астроцитоме, саркоме.

Растворимый в воде экстракт (порошок) из клеток Агарика Бразильского (Agaricus blazei Murill). 
Упаковка из 15 металлизированных пакетиков.
По 2 грамма препарата в пакетике.
Общий вес препарата – 30 грамм. 

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13 Осталось

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2 650 руб

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При покупке этого экстракта Bы получите 66 рублей скидки на следующий заказ.

Агарик бразильский. 
Agaricus blazei Murill.

Состав:
100% тело Agaricus blazei Murill.
Содержание полисахаридов: 45%.

Свидетельство о государственной регистрации: № RU.77.99.88.003.Е.003317.02.15 от 11.02.2015 г. Бланк №0262512  Смотреть на сайте Госрестра

Является заменителем препарата Lentinan (Лентинан).

Химический состав действующих веществ:
нейтральный полисахарид: бета-D-гликан (F1o-альфа-b);
пептид гликан: альфа-гликан (FA-1-альфа-альфа);
кислотный гетерополисахарид: бета-галактогликан (FA-1-альфа-бета);
нуклеиновая кислота (РНК) (FA-2-бета-бета);
рибонуклеотид протеин – белковый гликан FIII-2-бета (комплекс бета-(1-6)альфа-D-гликан и белок) и РНК (рибонуклеиновой кислоты);
нейтральный полисахарид – ксилогликан FIV-2-бета;
эргостерол и натриевый пироглютамат;
противоопухолевые липиды: 3.6% липидов, из которых 26.8% – нейтральные липиды, а 73.2% – фосфолипиды.

Фармакодинамика:
Противоопухолевое воздействие через усиление механизма противоопухолевой резистентности организма: направленная активация различных иммунных исполнительных элементов (возрастание NK-клеточной активности, усиление формирования цитотоксических Т-лимфоцитов (ЦТЛ), активизация макрофагов); увеличение их жизненного цикла;
противоангиогенное действие – блокирование роста собственной кровеносной системы опухоли;
способствует проникновению иммунных клеток внутрь опухоли, что увеличивает эффективность иммунного воздействия;
потенцирование различных лимфокинов (интерлейкина 1, 2 и 6);
увеличение синтеза альфа-ФНО (фактора некроза опухолей);
увеличение производства интерферона-альфа, и улучшение действия интерферона-гамма в 2-4 раза;
увеличение выработки перфоринов;
восстановление сниженной иммунологической реактивности, которая наблюдается при облучении или химиотерапии;
противодействие депрессивному воздействию цитостатиков на количество белых и красных кровяных клеток;
при химиотерапии и облучении облегчение таких симптомов, как: слабость, анорексия, рвота, сухость во рту, спонтанное потение и боль;
иммуномодуляция;
болеутоляющее действие;
противовоспалительные свойства;
гепатопротективный эффект, улучшение функционального состояния печени, уменьшение энзимопатии.

Основное действие:
Подавляет рост опухоли, останавливает распространения метастаз, включает процесс разрушения и уничтожения раковых клеток и метастаз, поднимает уровень иммунитета, сильно поддерживает организм в период химио- и лучевой терапии, снижает до минимума негативные последствия химио- и лучевой терапии, улучшает показатели анализов крови, притупляет болезненные ощущения, сильно увеличивает срок жизни. 

Читать подробно: ДЕЙСТВИЕ НА ОПУХОЛЬ >>

Суточная дозировка:
Профилактическая: 2 раза в день по 1 пакетику за 60 минут до или после еды.
Лечебная: 2-3 раза в день по одному пакетику за 60 минут до еды или после еды с обязательным сочетанием с другим препаратом.
Для достижения наилучших результатов рекомендуется принимать согласно правилам методики "ПРОГМА". Необходима наша консультация .
Не рекомендуется принимать более двух месяцев подряд.
Необходимо заменить на другой подходящий.

Описание:
Мелкодисперсный порошок, полностью растворимый в воде. Цвет может меняться от светлокоричневого до тёмно-коричневого.

Способ применения:
Высыпать содержимое пакетика в стакан со 100 мл горячей ~ 80°С воды, размешать до полного растворения порошка, охладить до приемлемой температуры. Выпить.

Побочные действия:
При повышенной чувствительности, в редких случаях, возможно появление лёгкой диспепсии. Редко наблюдались аллергические реакции, в виде крапивницы, на компоненты экстракта. На начальных стадиях приема возможно газообразование. Возможно понижение давления.

Противопоказания:
Только индивидуальная непереносимость.
Беременность, лактация - не проводились клинические испытания в этих группах.
Не желательно применять экстракт детям до 8 лет.

Взаимодействие с другими лекарственными средствами и продуктами:
Хорошо сочетается с цитостатиками. Также при терапии даёт более выраженный эффект в сочетании с экстрактами из других грибов. В этом случае дозы приёма экстракта должны быть скорректированы специалистом.

Условия хранения:
Хранить при комнатной температуре (5-25 °С) в оригинальной упаковке.

Производитель: 
Zhejiang Fangge Pharmaceutical Co., Ltd
QINGYUAN, CHINESE MUSHROOM CITY, No. 1 
ECOLOGICAL ENVIRONMENT TOWN OF CHINA,
ZHEJIANG PROVINCE
CHINA
Стандарт производства и качества: GMP (Good Manufacturing Practice)

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Chitosan oligosaccharides in combination with Agaricus blazei Murill extract reduces hepatoma formation in mice with severe combined immunodeficiency.

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Immunomodulatory effects of the Agaricus blazei Murrill-based mushroom extract AndoSan in patients with multiple myeloma undergoing high dose chemotherapy and autologous stem cell transplantation: a randomized, double blinded clinical study.

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The Medicinal Values of Culinary-Medicinal Royal Sun Mushroom (Agaricus blazei Murrill).

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A laccase with antiproliferative and HIV-I reverse transcriptase inhibitory activities from the mycorrhizal fungus Agaricus placomyces.

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Estrogen-like activity and dual roles in cell signaling of an Agaricus blazei Murrill mycelia-dikaryon extract.

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The Mushroom Agaricus blazei Murill Elicits Medicinal Effects on Tumor, Infection, Allergy, and Inflammation through Its Modulation of Innate Immunity and Amelioration of Th1/Th2 Imbalance and Inflammation.

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Phase I Clinical Study of the Dietary Supplement, Agaricus blazei Murill, in Cancer Patients in Remission.

Ohno S, Sumiyoshi Y, Hashine K, Shirato A, Kyo S, Inoue M.

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The effects of Agaricus sylvaticus fungi dietary supplementation on the metabolism and blood pressure of patients with colorectal cancer during post surgical phase.

Costa Fortes R, Carvalho Garbi Novaes MR.

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Effects of Agaricus blazei Murill extract on immune responses in normal BALB/c mice.

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BMC Complement Altern Med. 2007 Oct 29;7:32.

Therapy of myeloma in vivo using marine phospholipid in combination with Agaricus blazei Murill as an immune respond activator.

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Cancer Res. 1977 Apr;37(4):1133-6.

Inhibition of DNA polymerase from L1210 murine leukemia by a sulfhydryl reagent from agaricusbisporus.

Graham DG, Tye RW, Vogel FS.

Cancer Res. 1977 Feb;37(2):436-9.

Synthetic and naturally occurring hydrazines as possible cancer causative agents.

Toth B.

Cancer Res. 1975 Dec;35(12):3693-7.

Cytostatic, cytocidal and potential antitumor properties of a class of quinoid compounds, initiators of the dormant state in the spores of Agaricus bisporus.

Vogel FS, Kemper LA, McGarry SJ, Graham DG.

Am J Pathol. 1975 Jan;78(1):33-48.

Characterization of the cell surface receptor for the Agaricus bisporus hemagglutinin.

Presant CA, Kornfeld S.

J Biol Chem. 1972 Nov 10;247(21):6937-45. No abstract available. 

The effect of diesel-oil soot on differentiation of the cultivated mushroom: Agaricus campestris var. Bisporus.

HUGHES DT.

Br J Cancer. 1961 Mar;15:101-13. No abstract available.

Cordyceps militaris (L.) Link Fruiting Body Reduces the Growth of a Non-Small Cell Lung Cancer Cell Line by Increasing Cellular Levels of p53 and p21.

Bizarro A, Ferreira IC, Soković M, van Griensven LJ, Sousa D, Vasconcelos MH, Lima RT.

Molecules. 2015 Jul 31;20(8):13927-40. doi: 10.3390/molecules200813927.

A direct protein kinase B-targeted anti-inflammatory activity of cordycepin from artificially cultured fruit body of Cordyceps militaris.

Yoon JY, Kim JH, Baek KS, Kim GS, Lee SE, Lee DY, Choi JH, Kim SY, Park HB, Sung GH, Lee KR, Cho JY, Noh HJ.

Pharmacogn Mag. 2015 Jul-Sep;11(43):477-85. doi: 10.4103/0973-1296.160454.

Pro-Apoptotic Activity of 4-Isopropyl-2-(1-Phenylethyl) Aniline Isolated from Cordyceps bassiana.

Kim MS, Lee Y, Sung GH, Kim JH, Park JG, Kim HG, Baek KS, Cho JH, Han J, Lee KH, Hong S, Kim JH, Cho JY.

Biomol Ther (Seoul). 2015 Jul;23(4):367-73. doi: 10.4062/biomolther.2015.021. Epub 2015 Jul 1.

Antitumor and antimetastatic activities of chloroform extract of medicinal mushroom Cordyceps taii in mouse models.

Liu RM, Zhang XJ, Liang GY, Yang YF, Zhong JJ, Xiao JH.

BMC Complement Altern Med. 2015 Jul 9;15:216. doi: 10.1186/s12906-015-0762-9. Erratum in: BMC Complement Altern Med. 2015;15:284. 

Anti-cancer effect of Cordyceps militaris in human colorectal carcinoma RKO cells via cell cycle arrest and mitochondrial apoptosis.

Lee HH, Lee S, Lee K, Shin YS, Kang H, Cho H.

Daru. 2015 Jul 4;23:35. doi: 10.1186/s40199-015-0117-6.

Effects of cordycepin on the microglia-overactivation-induced impairments of growth and development of hippocampal cultured neurons.

Peng J, Wang P, Ge H, Qu X, Jin X.

PLoS One. 2015 May 1;10(5):e0125902. doi: 10.1371/journal.pone.0125902. eCollection 2015.

Antiproliferative and Apoptosis-Inducing Activities of 4-Isopropyl-2,6-bis(1-phenylethyl)phenol Isolated from Butanol Fraction of Cordyceps bassiana.

Kim JH, Lee Y, Sung GH, Kim HG, Jeong D, Park JG, Baek KS, Sung NY, Yang S, Yoon DH, Lee SY, Kang H, Song C, Cho JH, Lee KH, Kim TW, Cho JY.

Evid Based Complement Alternat Med. 2015;2015:739874. doi: 10.1155/2015/739874. Epub 2015 Apr 2.

Toxicity evaluation of cordycepin and its delivery system for sustained in vitro anti-lung cancer activity.

Aramwit P, Porasuphatana S, Srichana T, Nakpheng T.

Nanoscale Res Lett. 2015 Mar 27;10:152. doi: 10.1186/s11671-015-0851-1. eCollection 2015.

Cordycepin (3'-deoxyadenosine) suppressed HMGA2, Twist1 and ZEB1-dependent melanoma invasion and metastasis by targeting miR-33b.

Zhang P, Huang C, Fu C, Tian Y, Hu Y, Wang B, Strasner A, Song Y, Song E.

Oncotarget. 2015 Apr 30;6(12):9834-53.

Tissue invasion and metastasis: Molecular, biological and clinical perspectives.

Jiang WG, Sanders AJ, Katoh M, Ungefroren H, Gieseler F, Prince M, Thompson SK, Zollo M, Spano D, Dhawan P, Sliva D, Subbarayan PR, Sarkar M, Honoki K, Fujii H, Georgakilas AG, Amedei A, Niccolai E, Amin A, Ashraf SS, Ye L, Helferich WG, Yang X, Boosani CS, Guha G, Ciriolo MR, Aquilano K, Chen S, Azmi AS, Keith WN, Bilsland A, Bhakta D, Halicka D, Nowsheen S, Pantano F, Santini D.

Semin Cancer Biol. 2015 Dec;35 Suppl:S244-75. doi: 10.1016/j.semcancer.2015.03.008. Epub 2015 Apr 10. Review.

Korean medicine therapy as a substitute for chemotherapy for metastatic breast cancer: a case report.

Lee DH, Kim SS, Seong S, Kim N, Han JB.

Case Rep Oncol. 2015 Feb 10;8(1):64-71. doi: 10.1159/000375292. eCollection 2015 Jan-Apr.

Anticancer and antimetastatic effects of cordycepin, an active component of Cordyceps sinensis.

Nakamura K, Shinozuka K, Yoshikawa N.

J Pharmacol Sci. 2015 Jan;127(1):53-6. doi: 10.1016/j.jphs.2014.09.001. Epub 2014 Oct 2. Review.

A case of metastatic bladder cancer in both lungs treated with korean medicine therapy alone.

Lee DH, Kim SS, Seong S, Woo CR, Han JB.

Case Rep Oncol. 2014 Jul 30;7(2):534-40. doi: 10.1159/000365884. eCollection 2014 May.

Induction of apoptosis by Cordyceps militaris fraction in human chronic myeloid leukemia K562 cells involved with mitochondrial dysfunction.

Tian T, Song L, Zheng Q, Hu X, Yu R.

Pharmacogn Mag. 2014 Jul;10(39):325-31. doi: 10.4103/0973-1296.137374.

Bioactive proteins and peptides isolated from Chinese medicines with pharmaceutical potential.

Wong KL, Wong RN, Zhang L, Liu WK, Ng TB, Shaw PC, Kwok PC, Lai YM, Zhang ZJ, Zhang Y, Tong Y, Cheung HP, Lu J, Sze SC.

Chin Med. 2014 Jul 19;9:19. doi: 10.1186/1749-8546-9-19. eCollection 2014. Review.

Cordycepin down-regulates multiple drug resistant (MDR)/HIF-1α through regulating AMPK/mTORC1 signaling in GBC-SD gallbladder cancer cells.

Wu WD, Hu ZM, Shang MJ, Zhao DJ, Zhang CW, Hong DF, Huang DS.

Int J Mol Sci. 2014 Jul 18;15(7):12778-90. doi: 10.3390/ijms150712778.

Effects of Fermented Mushroom of Cordyceps sinensis, Rich in Selenium, on Uterine Cervix Cancer.

Ji J, Liu J, Liu H, Wang Y.

Evid Based Complement Alternat Med. 2014;2014:173180. doi: 10.1155/2014/173180. Epub 2014 May 25.

Cordyceps cicadae induces G2/M cell cycle arrest in MHCC97H human hepatocellular carcinoma cells: a proteomic study.

Wang H, Zhang J, Sit WH, Lee CY, Wan JM.

Chin Med. 2014 May 8;9:15. doi: 10.1186/1749-8546-9-15. eCollection 2014.

Anti-cancer effects of CME-1, a novel polysaccharide, purified from the mycelia of Cordycepssinensis against B16-F10 melanoma cells.

Jayakumar T, Chiu CC, Wang SH, Chou DS, Huang YK, Sheu JR.

J Cancer Res Ther. 2014 Jan-Mar;10(1):43-9. doi: 10.4103/0973-1482.131365.

Cordycepol C induces caspase-independent apoptosis in human hepatocellular carcinoma HepG2 cells.

Sun YS, Lv LX, Zhao Z, He X, You L, Liu JK, Li YQ.

Biol Pharm Bull. 2014;37(4):608-17.

A Case of Stage IV Non-Small Cell Lung Cancer Treated with Korean Medicine Therapy Alone.

Lee DH, Seong S, Kim SS, Han JB.

Case Rep Oncol. 2013 Nov 15;6(3):574-8. doi: 10.1159/000356061. eCollection 2013.

Cordycepin regulates GSK-3β/β-catenin signaling in human leukemia cells.

Ko BS, Lu YJ, Yao WL, Liu TA, Tzean SS, Shen TL, Liou JY.

PLoS One. 2013 Sep 26;8(9):e76320. doi: 10.1371/journal.pone.0076320. eCollection 2013.

Cordyceps militaris and mycelial fermentation induced apoptosis and autophagy of human glioblastoma cells.

Yang CH, Kao YH, Huang KS, Wang CY, Lin LW.

Cell Death Dis. 2012 Nov 29;3:e431. doi: 10.1038/cddis.2012.172.

Recent developments in mushrooms as anti-cancer therapeutics: a review.

Patel S, Goyal A.

3 Biotech. 2012 Mar;2(1):1-15. Epub 2011 Nov 25.

Cordyceps militaris Grown on Germinated Soybean Induces G2/M Cell Cycle Arrest through Downregulation of Cyclin B1 and Cdc25c in Human Colon Cancer HT-29 Cells.

Mollah ML, Park DK, Park HJ.

Evid Based Complement Alternat Med. 2012;2012:249217. doi: 10.1155/2012/249217. Epub 2012 Mar 12.

Pro-apoptotic effects of Paecilomyces hepiali, a Cordyceps sinensis extract on human lung adenocarcinoma A549 cells in vitro.

Thakur A, Hui R, Hongyan Z, Tian Y, Tianjun C, Mingwei C.

J Cancer Res Ther. 2011 Oct-Dec;7(4):421-6. doi: 10.4103/0973-1482.92007.

A toxicological study of HangAmDan-B in mice.

Yoo HS, Lee HJ, Kim JS, Yoon J, Lee GH, Lee YW, Cho CK.

J Acupunct Meridian Stud. 2011 Mar;4(1):54-60. doi: 10.1016/S2005-2901(11)60007-1.

Ethanolic and aqueous extracts derived from Australian fungi inhibit cancer cell growth in vitro.

Beattie KD, Ulrich R, Grice ID, Uddin SJ, Blake TB, Wood KA, Steele J, Iu F, May TW, Tiralongo E.

Mycologia. 2011 May-Jun;103(3):458-65. doi: 10.3852/10-121. Epub 2011 Jan 24.

Antitumor activity of water extracts from Cordyceps militaris in NCI-H460 cell xenografted nude mice.

Park SE, Kim J, Lee YW, Yoo HS, Cho CK.

J Acupunct Meridian Stud. 2009 Dec;2(4):294-300. doi: 10.1016/S2005-2901(09)60071-6.

Cordycepin Suppresses Expression of Diabetes Regulating Genes by Inhibition of Lipopolysaccharide-induced Inflammation in Macrophages.

Shin S, Lee S, Kwon J, Moon S, Lee S, Lee CK, Cho K, Ha NJ, Kim K.

Immune Netw. 2009 Jun;9(3):98-105. doi: 10.4110/in.2009.9.3.98. Epub 2009 Jun 30.

Antifungal and Anticancer Activities of a Protein from the Mushroom Cordyceps militaris.

Park BT, Na KH, Jung EC, Park JW, Kim HH.

Korean J Physiol Pharmacol. 2009 Feb;13(1):49-54. doi: 10.4196/kjpp.2009.13.1.49. Epub 2009 Feb 28.

Inhibitory effect of cordycepin on hematogenic metastasis of B16-F1 mouse melanoma cells accelerated by adenosine-5'-diphosphate.

Yoshikawa N, Kunitomo M, Kagota S, Shinozuka K, Nakamura K.

Anticancer Res. 2009 Oct;29(10):3857-60.

Induction of apoptosis by aqueous extract of Cordyceps militaris through activation of caspases and inactivation of Akt in human breast cancer MDA-MB-231 Cells.

Jin CY, Kim GY, Choi YH.

J Microbiol Biotechnol. 2008 Dec;18(12):1997-2003.

Cordycepin inhibits IL-1beta-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts.

Noh EM, Kim JS, Hur H, Park BH, Song EK, Han MK, Kwon KB, Yoo WH, Shim IK, Lee SJ, Youn HJ, Lee YR.

Rheumatology (Oxford). 2009 Jan;48(1):45-8. doi: 10.1093/rheumatology/ken417.

Blockade of the aryl hydrocarbon receptor pathway triggered by dioxin, polycyclic aromatic hydrocarbons and cigarette smoke by Phellinus linteus.

Mukai M, Kasai A, Hiramatsu N, Hayakawa K, Okamura M, Tagawa Y, Yao J, Nakamura T, Kitamura M.

Biol Pharm Bull. 2008 Oct;31(10):1888-93.

Antioxidative and antimutagenic activities of 70% ethanolic extracts from four fungal mycelia-fermented specialty rices.

Ra Yoon M, Hyun Nam S, Young Kang M.

J Clin Biochem Nutr. 2008 Sep;43(2):118-25. doi: 10.3164/jcbn.2008056.

Apoptosis of human hepatocarcinoma (HepG2) and neuroblastoma (SKN-SH) cells induced by polysaccharides-peptide complexes produced by submerged mycelial culture of an entomopathogenic fungus Cordyceps sphecocephala.

Oh JY, Baek YM, Kim SW, Hwang HJ, Hwang HS, Lee SH, Yun JW.

J Microbiol Biotechnol. 2008 Mar;18(3):512-9.

Cordyceps sinensis health supplement enhances recovery from taxol-induced leukopenia.

Liu WC, Chuang WL, Tsai ML, Hong JH, McBride WH, Chiang CS.

Exp Biol Med (Maywood). 2008 Apr;233(4):447-55. doi: 10.3181/0708-RM-230.

Reinforcement of antitumor effect of Cordyceps sinensis by 2'-deoxycoformycin, an adenosine deaminase inhibitor.

Yoshikawa N, Nakamura K, Yamaguchi Y, Kagota S, Shinozuka K, Kunitomo M.

In Vivo. 2007 Mar-Apr;21(2):291-5.

New diphenyl ethers from the insect pathogenic fungus Cordyceps sp. BCC 1861.

Bunyapaiboonsri T, Yoiprommarat S, Intereya K, Kocharin K.

Chem Pharm Bull (Tokyo). 2007 Feb;55(2):304-7.

Mycelium cultivation, chemical composition and antitumour activity of a Tolypocladium sp. fungus isolated from wild Cordyceps sinensis.

Leung PH, Zhang QX, Wu JY.

J Appl Microbiol. 2006 Aug;101(2):275-83.

Induction of apoptosis by Cordyceps militaris through activation of caspase-3 in leukemia HL-60 cells.

Lee H, Kim YJ, Kim HW, Lee DH, Sung MK, Park T.

Biol Pharm Bull. 2006 Apr;29(4):670-4.

Effects of Cordyceps militaris extract on angiogenesis and tumor growth.

Yoo HS, Shin JW, Cho JH, Son CG, Lee YW, Park SY, Cho CK.

Acta Pharmacol Sin. 2004 May;25(5):657-65.

Cordyceps sinensis and its fractions stimulate MA-10 mouse Leydig tumor cell steroidogenesis.

Huang BM, Ju SY, Wu CS, Chuang WJ, Sheu CC, Leu SF.

J Androl. 2001 Sep-Oct;22(5):831-7.

Inhibitory effect of Cordyceps sinensis on spontaneous liver metastasis of Lewis lung carcinoma and B16 melanoma cells in syngeneic mice.

Nakamura K, Yamaguchi Y, Kagota S, Kwon YM, Shinozuka K, Kunitomo M.

Jpn J Pharmacol. 1999 Mar;79(3):335-41.

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